Laboratory investigations include:
- General blood test, assessing hemoglobin level, red blood cells, hematocrit, leukocytes, and platelets.
- Biochemical analysis, evaluating kidney and liver function, as well as protein content.
- Immunological tests, including anticardiolipin antibodies and lupus anticoagulant.
- Blood coagulogram.
- Measurement of thyroid hormones and thyroid-stimulating hormone (TSH).
- An HIV serological test is conducted as needed to determine the cause of pulmonary hypertension.
Patients diagnosed with idiopathic pulmonary hypertension often exhibit elevated levels of serum uric acid. Additionally, increased plasma concentrations of brain natriuretic peptide (BNP) are indicative of right ventricular failure. These, along with heightened serum levels of norepinephrine, endothelin-1, and troponin T, are considered factors associated with a poor prognosis.