The cardiopulmonary stress test is employed to evaluate ventilation and gas exchange during controlled physical activity, providing indices such as the peak oxygen consumption index and anaerobic threshold.

In individuals with pulmonary hypertension (PH), there is a reduction in both the anaerobic threshold and peak oxygen consumption. While the cardiopulmonary stress test was utilized in previous multicenter studies, it failed to demonstrate clear advantages over the 6-minute walk test. This is due to its technical complexity, inability to assess therapy effectiveness, and results that are contingent on the expertise of the medical personnel conducting the test.

PATIENT QUESTIONNAIRE